Acid-Catalyzed, Metal- and Oxidant-Free C=C Bond Cleavage of Enaminones: One-Pot Synthesis of 3,4-Dihydroquinazolines.

In this study, we present the HOAc-catalyzed selective cleavage of the C=C double bond of enaminones, enabling the formation of a new C-N bond and a new C=N bond for the one-pot synthesis of 2-substituted 3,4-dihydroquinazolines directly from ynones and 2-(aminomethyl)anilines. This method operates in ethanol under transition-metal-free and oxidant-free conditions, offering a sustainable and efficient approach for the synthesis of 3,4-dihydroquinazolines with broad functional group tolerance.

Effects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia.

Background: Gestational hypertension and preeclampsia are potentially linked to similar pathophysiological processes. Maternal preeclampsia increases the occurrence of early-onset neonatal thrombocytopenia. We hypothesized that maternal gestational hypertension may impact the incident early-onset neonatal thrombocytopenia.

Increased use of damage control laparotomy for emergency small bowel or colon surgery: does it affect patient outcomes?

Purpose: Evidence to guide the application of damage control laparotomy (DCL) in emergency surgery patients is limited. We assessed whether DCL use for emergent small bowel or colon surgery increased over time and its impact on outcomes. We hypothesized that DCL would be utilized more often in patients with significant comorbidities or septic shock with improved outcomes.

Effects of Illegal Solid Waste Dumping on the Structure of Soil Bacterial Communities: A Case Study in China.

Illegal solid waste dumping is a significant factor contributing to environmental damage. In this study, 16S rRNA gene sequencing technology was used for the identification and assessment of environmental damage in an illegal dumping area in China, with the aim of confirming environmental damage through analyzing changes in the soil bacterial communities across slag, sewage sludge, and non-contaminated areas. The results indicate that the diversity of soil bacteria decreases with an increase in the degree of pollution.

Two leucine-rich repeat receptor-like kinases initiate herbivory defense responses in tea plants.

Leucine-rich repeat receptor-like kinases (LRR-RLKs) have emerged as key regulators of herbivory perception and subsequent defense initiation. While their functions in grass plants have been gradually elucidated, the roles of herbivory-related LRR-RLKs in woody plants remain largely unknown. In this study, we mined the genomic and transcriptomic data of tea plants () and identified a total of 307 CsLRR-RLK members.