Isotretinoin and acne in practice: a prospective analysis of 188 cases over 9 years.

A total of 188 acne patients (113 male and 75 female) with a mean age of 25 years (range 15-42 years) were treated with isotretinoin in doses ranging from 0.5 to 1 mg/kg. The study lasted 9 years.

[Decrease of the sebum excretion rate and improvement of acne in acneic women treated with the association: cyproterone acetate-ethinyl estradiol (author's transl)].

37 women have received during a total of 429 cycles (mean 12 cycles/patients) an association containing cyproterone acetate 2 mg and ethinyl estradiol 0.05 mg. A marked improvement in the clinical symptoms (acne 35 cases) has been observed.