Publications by authors named "M J W Greuter"
Article Synopsis
- The study examines how the COVID-19 pandemic affected colorectal cancer screening rates and intervals in Flanders, Belgium, focusing on the impact of socioeconomic status (SES).
- Analysis revealed that during the pandemic, areas with lower population density and lower income saw decreases in screening uptake, while wealthier areas tended to have increased delays in screening intervals.
- The findings suggest a need for targeted communication strategies to encourage screening participation among low SES populations and timely reminders for those delaying their screenings.
Objectives: The World Health Organization supports both the screen-and-treat (ST) approach and the screen, triage and treat (STT) approach to cervical cancer screening using high-risk human papillomavirus (hrHPV) testing. For Uganda, the sequence of hrHPV-ST and hrHPV-STT could be similar, with visual inspection with acetic acid (VIA) after positive hrHPV tests in both. To consider potential tradeoffs (overtreatment in ST versus missed cancer cases in STT), we compared hrHPV-STT with VIA triage (STT-VIA), and STT with HPV 16/18 genotyping risk stratification, to hrHPV-ST for Uganda, in terms of overtreatment, cervical cancer incidence, and life years, for the general female population of Uganda.
View Article and Find Full Text PDFBackground: Uganda has a high burden of cervical cancer and its current coverage of screening based on visual inspection with acetic acid (VIA) is low. High-risk HPV (hrHPV) testing is recommended by the World Health Organization as part of the global elimination strategy for cervical cancer. In this context, country-specific health economic evaluations can inform national-level decisions regarding implementation.
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- Colonoscopy surveillance for colorectal cancer (CRC) can be burdensome for patients, and stool tests might help reduce the need for colonoscopies by identifying individuals at higher risk.
- This study involved 3453 participants aged 50-75 who completed multiple stool tests and colonoscopies to assess the accuracy of these methods for detecting advanced neoplasia.
- Results indicated that stool-based strategies could effectively reduce colonoscopy frequency by 15%-41% while being safer and more cost-effective, particularly with fecal immunochemical tests (FITs), although multitarget stool DNA testing was found to be more expensive.
Article Synopsis
- The study evaluates strategies for colorectal cancer (CRC) surveillance in individuals with familial CRC risk, comparing different methods of colonoscopy and fecal testing.
- The optimal strategy identified is a combination of 10-yearly colonoscopy and 2-yearly FIT from ages 40 to 80, which enhances life quality and reduces costs.
- This approach not only prevents more CRC deaths but also significantly decreases the number of colonoscopies required compared to current guidelines.