Publications by authors named "M J Terry"
Low-grade gliomas and reactive piloid gliosis can present with overlapping features on conventional histology. Given the large implications for patient treatment, there is a need for effective methods to discriminate these morphologically similar but clinically distinct entities. Using routinely available stains, we hypothesize that a limited panel including SOX10, p16, and cyclin D1 may be useful in differentiating mitogen-activated protein (MAP) kinase-activated low-grade gliomas from piloid gliosis.
View Article and Find Full Text PDFPurpose: To identify areas of consensus among experts on the performance of endothelial keratoplasty by using a modified Delphi approach, to help create a framework for novice surgeons to adopt these procedures.
Methods: Thirty-one international experts in endothelial keratoplasty participated. Two rounds of electronic survey were followed by a hybrid, virtual meeting.
Article Synopsis
- Recent studies indicate a rise in early-onset cancer cases under age 50, raising questions about whether this increase is due to earlier detection or a real rise in cancer risk.
- The authors propose a modified Multi-Stage Clonal Expansion model that includes tumor size at diagnosis and improved detection methods to differentiate between apparent effects and true increases in risk.
- Their analysis of colorectal, breast, and thyroid cancers shows that more recent birth cohorts experience faster cancer progression, supporting the idea of real increases in early-onset cancer risk rather than solely improved diagnostics.
Menopausal users of hormone replacement therapy (HRT) are at increased breast cancer risk and decreased colorectal cancer (CRC) risk compared with individuals who have never used HRT, but these opposing associations may differ by familial risk of breast cancer and CRC. We harmonized data from 3 cohorts and generated separate breast cancer and CRC familial risk scores based on cancer family history. We defined moderate or strong family history as a risk score of 0.
View Article and Find Full Text PDF