Atezolizumab in High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Randomized Clinical Trial.

Importance: Treating locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) involves any combination of surgery, radiation, and chemotherapy, followed by routine monitoring for local recurrence or distant metastases. Given the poor patient outcomes, a significant unmet clinical need for improved treatment options remains.

Objective: To evaluate efficacy and safety of maintenance atezolizumab in patients with LA SCCHN at high risk of disease progression after multimodal definitive treatment.

Exploring the relationship between religiosity and telomere length in older individuals.

Objectives: Although telomere length is an established marker of biological aging, the impact of religious beliefs on telomere length remains uncertain.

Methods: This cross-sectional study investigated the relationship between religiosity and telomere length among senior Brazilians, aged 60 and older. The study examined the association between organizational, non-organizational, and intrinsic religiosity with telomere length, adjusting for sociodemographic, mental, physical health, and medication.

Severe Chronic Suppurative Osteomyelitis Following Dental Implant Placement.

Osteomyelitis is an infection caused by bacterial contamination of the bone marrow, cortical surfaces, and the periosteum. The clinical examination of a patient with severe osteomyelitis secondary to dental implants revealed a large facial swelling, suppuration in the perimandibular region, limited mouth opening, and diffuse pain that started after the placement of five dental implants. Two failed implants were removed, a reconstructive titanium plate was placed, and the patient was treated with antibiotics, but the infection did not resolve.

Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study.

This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.