Publications by authors named "M J Tabernero"
Rhabdoid meningiomas (RM) are a rare meningioma subtype with a heterogeneous clinical course which is more frequently associated with recurrence, even among tumors undergoing-complete surgical removal. Here, we retrospectively analyzed the clinical-histopathological and cytogenetic features of 29 tumors, from patients with recurrent (seven primary and 14 recurrent tumors) vs. non-recurrent RM ( = 8).
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- The Kaplan-Meier method can overestimate the risk of cancer coming back, especially when other events like death happen first, but the Aalen-Johansen method can give a more accurate picture by considering these events.
- A study looked at research articles about meningiomas (a type of brain tumor) since 2020 and found that only a few used the better method.
- It showed that not using the Aalen-Johansen method mostly led to overestimating the recurrence risk, especially in older patients with more serious tumors.
Rhabdoid meningiomas (RM) shows heterogeneous histological findings, and a wide variety of chromosomal copy number alterations (CNA) are associated with an unpredictable course of the disease. In this study, we analyzed a series of 305 RM samples from patients previously reported in the literature and 33 samples from 23 patients studied in our laboratory. Monosomy 22-involving the minimal but most common recurrent region loss of the 22q11.
View Article and Find Full Text PDFErratum to "Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43" [EBioMedicine 62, December 2020] DOI: https://doi.org/10.1016/j.ebiom.2020.103134.
EBioMedicine
December 2021
Article Synopsis
- Human WHO grade 1 meningiomas, although typically benign, are responsible for about 50% of recurrent cases, highlighting the need for more research on their genetic profiles and patient outcomes.
- The study investigated 32 grade 1 meningiomas through whole exome sequencing, revealing diverse genetic variants mainly affecting specific genes, with distinct profiles linked to patient recurrence-free survival (RFS).
- The analysis identified four genetic profiles related to prognosis: two good-prognosis subgroups with high RFS rates and two poor-prognosis subgroups with significantly lower RFS rates, emphasizing the complexity of these tumors and their impact on treatment outcomes.*