Publications by authors named "M J T de Alaniz"
In this study, we used emerging community engagement frameworks to describe the structure and outcomes of a large-scale, community-engaged, research-to-practice initiative, RADx-UP. Qualitative methods were used to analyze survey and meeting data from 2022 for RADx-UP projects. Most projects had diverse partners, achieved moderate levels of community engagement, and experienced positive outcomes.
View Article and Find Full Text PDFThe role of community outreach and engagement in evaluation of NCI Cancer Center Support Grants.
Cancer Causes Control
January 2024
Purpose: National Cancer Institute (NCI)-designated cancer centers are required to consider their impact on the catchment area they serve. These activities are facilitated by community outreach and engagement (COE) activities as specified in the Cancer Center Support Grant (CCSG) request for applications. While the critical importance of COE activities to NCI-designated cancer centers is well known, it is less clear what impact the COE component has on the overall CCSG merit descriptor and score.
View Article and Find Full Text PDFObjective: Synonymous variants can lead to disease; nevertheless, the majority of sequencing studies conducted in Alzheimer disease (AD) only assessed coding variation.
Methods: To detect synonymous variants modulating AD risk, we conducted a whole-genome sequencing study on 67 Caribbean Hispanic (CH) families multiply affected by AD. Identified disease-associated variants were further assessed in an independent cohort of CHs, expression quantitative trait locus (eQTL) data, brain autopsy data, and functional experiments.
Role of Tau Protein in Remodeling of Circadian Neuronal Circuits and Sleep.
Front Aging Neurosci
November 2019
Article Synopsis
- Circadian clocks synchronize various bodily functions into daily rhythms, but neurodegenerative diseases like Alzheimer's disrupt these rhythms, sleep patterns, and cognitive abilities, though the reasons for this are still unclear.
- Researchers explored how the tau protein affects neuronal circadian biology, utilizing a tau-deficient model to show that losing tau leads to disrupted circadian rhythms and sleep.
- The absence of tau alters the structural plasticity of key circadian neurons and affects core clock protein levels, indicating that tau plays a crucial role in maintaining the functionality and connectivity of circadian networks.
Background: Multi-Resistant Organisms (MRO) healthcare-associated infections (HAI) are closely associated with contamination of surfaces. Outsourced companies are usually in charge of both hospital hygiene and environmental hygiene personnel (EHP) supervision, which can result in bias.
Methods: A quasi-experimental study.