Publications by authors named "M J Sutcliffe"
Yorkshire and the Humber GP trainee perspectives on incomplete evidence outcomes at ARCP.
Educ Prim Care
December 2024
June 2023 saw an exceptionally high proportion of Outcome 5s (incomplete evidence) issued at the annual review of competency progression (ARCP) for GP Trainees in Yorkshire and the Humber (Y&H) Deanery. These outcomes created considerable time, administrative and financial costs for the deanery. Additionally, it was believed that receiving non-standard outcomes at ARCP would be detrimental to trainee wellbeing.
View Article and Find Full Text PDFThe kinome is a dynamic system of kinases regulating signaling networks in cells and dysfunction of protein kinases contributes to many diseases. Regulation of the protein expression of kinases alters cellular responses to environmental changes and perturbations. We configured a library of 672 proteotypic peptides to quantify >300 kinases in a single LC-MS experiment using ten micrograms protein from human tissues including biopsies.
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- - Approximately 14% of older adults in the UK are at risk of malnutrition, and screening in primary care could improve their quality of life and reduce healthcare use.
- - The study developed an intervention (screen and treat protocol) to help primary care practitioners identify and support at-risk older adults and included interviews to gather insights from both practitioners and patients.
- - Key findings reveal that while patients often resist advice about malnutrition, they appreciate nutritional support; meanwhile, practitioners face logistical challenges and varying levels of engagement and understanding regarding the intervention’s goals.
Article Synopsis
- Lateral hinge fractures are a major concern in medial opening wedge high tibial osteotomy, and the optimal osteotomy apex position can help reduce these risks based on finite element analysis of stress and strain.
- A study analyzed the impact of hinge position on fracture risk across various knee models and found that hinge width and height significantly affect intra-operative stress and postoperative stability.
- The recommended apex location should be at the height of the fibular head and hinge width should be 13% of the tibia’s medial-lateral width to minimize fracture risk while ensuring stability, applicable regardless of tibia size.
Article Synopsis
- The use of living biological samples is crucial for preserving and documenting biological diversity, requiring reliable identification and data association for effective use and exchange of these materials.
- There is currently no standardized naming system for identifying animal biological materials, which can lead to misidentification and data loss.
- A newly proposed naming scheme aims to create unique identifiers for animal cellular materials, particularly for wildlife species, enhancing traceability and supporting long-term conservation efforts and biomedical research.