Publications by authors named "M J Struijs"
This first-in-human study (NCT03032588), conducted in Belgium, evaluated a new inactivated poliovirus vaccines (IPV) candidate based on Sabin poliovirus strains grown on the high-yield PER.C6® cell line. Healthy adults (N = 32) were randomized (1:1) to receive a single dose of PER.
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- This report analyzes the long-term effects of using plerixafor with G-CSF for stem cell mobilization in patients with non-Hodgkin lymphoma (NHL) and multiple myeloma (MM).
- The study included 167 NHL patients and 163 MM patients, comparing outcomes of those treated with plerixafor versus a placebo over a 5-year period.
- Results showed no significant differences in overall survival (OS) or progression-free survival (PFS) between the treatment groups, indicating that adding plerixafor did not improve survival outcomes for either NHL or MM patients.
Background: Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) play important roles in chronic intestinal inflammation. Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants and is characterized by acute intestinal inflammation and necrosis. The objective of the study is to investigate the role of ER stress and the UPR in NEC patients.
View Article and Find Full Text PDFBackground & Aims: Efforts are directed at reaching the optimal composition of pediatric amino acids (AA) infusions. The goal was to demonstrate the safety and efficacy of a newly developed parenteral AA solution containing alanyl-glutamine (GLN-AA) compared to Standard-AA.
Methods: This is a randomized (2:1), double-blind, multicentre clinical pilot trial.