The Potential Roles Played by miR-2113 and miR-568 in the Severe SARS-CoV-2 Infection Pathogenesis.

Background: Severe SARS-CoV-2 infection is significantly associated with over-expression of some immune-related molecules and inflammation. MicroRNAs are known to regulate the expression of various molecules, including those related to immune function. However, the specific roles played by miR-2113 and miR-568 in the pathogenesis of severe COVID-19 remain unclear.

Deep sequencing reveals 50 novel genes for recessive cognitive disorders.

Common diseases are often complex because they are genetically heterogeneous, with many different genetic defects giving rise to clinically indistinguishable phenotypes. This has been amply documented for early-onset cognitive impairment, or intellectual disability, one of the most complex disorders known and a very important health care problem worldwide. More than 90 different gene defects have been identified for X-chromosome-linked intellectual disability alone, but research into the more frequent autosomal forms of intellectual disability is still in its infancy.