Publications by authors named "M J Soloski"
Introduction: Although lymphopenia has been described in acute Lyme disease (LD), the complete blood count (CBC) has not been comprehensively examined, nor have sex-based analyses been conducted. We analyzed CBC values and identified sex-based trends among patients with early LD by comparing both to controls without a history of LD and to patients' pre-morbid values.
Methods: We enrolled participants from the Mid-Atlantic US with diagnostic erythema migrans and controls with no history of LD.
Article Synopsis
- Anti-HMGCR-positive immune-mediated necrotising myopathy (IMNM) is linked to IgG autoantibodies against HMGCR and specific HLA-DR alleles, but HMGCR-specific CD4T-cells had not been previously identified in affected patients.
- This study demonstrated that patients with anti-HMGCR+IMNM show heightened CD4T-cell responses to HMGCR compared to those with dermatomyositis, with a significant correlation between these responses and the levels of anti-HMGCR antibodies.
- The presence of distinct HMGCR-reactive CD4T-cells in both blood and muscle tissues highlights their potential role in the disease's development.
Background: Platelet "Microvesicles" (MVs) are studied for their role in blood coagulation and inflammation. The study aimed to establish if MVs are related to age, plasma levels of inflammation, coagulation, and fibrinolysis markers in healthy individuals.
Methods: We prospectively enrolled volunteers aged over 18 years.
Dendritic cells bridge the innate and adaptive immune responses by serving as sensors of infection and as the primary APCs responsible for the initiation of the T cell response against invading pathogens. The naive T cell activation requires the following three key signals to be delivered from dendritic cells: engagement of the TCR by peptide Ags bound to MHC molecules (signal 1), engagement of costimulatory molecules on both cell types (signal 2), and expression of polarizing cytokines (signal 3). Initial interactions between Borrelia burgdorferi, the causative agent of Lyme disease, and dendritic cells remain largely unexplored.
View Article and Find Full Text PDFArticle Synopsis
- Bacterial pneumonia can be more dangerous for newborns than for older kids, leading to serious health problems.
- Researchers studied how the immune systems of baby mice and slightly older mice respond to pneumonia, measuring changes in their lungs over time.
- They found that newborn mice had different immune cell responses compared to older mice, which helps explain why babies are more at risk for getting really sick from pneumonia.