Publications by authors named "M J Skov"
Aim: Knowledge about the clinical role that respiratory viruses play in infants and toddlers with cystic fibrosis (CF) remains limited. We determined the prevalence of respiratory viruses in routine respiratory secretion samples in children aged 0-3 years with CF. Associations with bacterial infections, respiratory tract symptoms and lung function were also explored.
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- The study investigates neuromuscular junction (NMJ) function in patients with Charcot-Marie Tooth (CMT) disease and explores the potential for improving muscle strength through ClC-1 channel inhibition.
- Results showed significant NMJ abnormalities in CMT patients, such as increased jitter and blocking, which correlated with weaker muscle performance and endurance.
- Preclinical experiments indicated that a new drug, NMD670, improved muscle strength and endurance in CMT mice, suggesting that targeting NMJ dysfunction might offer a new therapeutic approach for CMT patients.
Article Synopsis
- The study investigates the potential development of intraspinal pressure (ISP) elevation following traumatic spinal cord injury (TSCI) in a porcine model, particularly focusing on a hypothesized subdural compartment syndrome.
- Researchers conducted a randomized, sham-controlled trial over 72 hours measuring ISP changes alongside various injury protocols to assess the impact of different contusion regimes on ISP.
- Results showed no significant difference in ISP increases between TSCI and sham animals, indicating that the observed ISP changes were likely due to the surgical procedures rather than TSCI itself.
Background: People living with cystic fibrosis in Denmark had early, universal access to triple modulator treatment with elexacaftor/tezacaftor/ivacaftor. Close monitoring allowed us to assess the impact of treatment on lung function and progression of lung disease in an unselected nationwide cystic fibrosis population from 6 years of age.
Methods: Data were analysed using linear mixed-effect models to assess changes in levels and annual rates of change (slopes) in percent predicted (pp) forced expiratory volume in 1 s (FEV), forced vital capacity (FVC) and forced expiratory flow at 25-75% of FVC (ppFEF) between the 12 months pre-treatment and treatment periods.
Background Context: Elevation of mean arterial blood pressure (MAP) has been proposed to raise spinal cord blood flow (SCBF) after traumatic spinal cord injury (TSCI). Current clinical guidelines for cervical TSCI suggest maintaining MAP 85-90 mmHg for 5-7 days using vasopressors, eg, noradrenaline. However, it remains unknown whether these interventions that promote an increased systemic MAP result in improved perfusion in the spinal cord.
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