Pediatric Myelodysplastic Syndrome with SF3B1 Mutation.

Patients with Fanconi Anemia (FA) have an increased risk of developing myeloid malignancies, which often precede the diagnosis of FA. We describe a patient with non-specific clinical findings diagnosed with myelodysplastic syndrome (MDS) at 17 years of age. A pathogenic SF3B1 alteration was identified and prompted evaluation for a bone marrow failure syndrome.

The emerging therapeutic potential of extracellular vesicles in trauma.

Traumatic injury is a major cause of morbidity and mortality worldwide, despite significant advances in treatments. Most deaths occur either very early, through massive head trauma/CNS injury or exsanguination (despite advances in transfusion medicine), or later after injury often through multiple organ failure and secondary infection. Extracellular vesicles (EVs) are known to increase in the circulation after trauma and have been used to limited extent as diagnostic and prognostic markers.

Fibrous dysplasia.

An atypical presentation of fibrous dysplasia with a very large cystic component is described. The MR pattern was not diagnostic.

Orbital meningioma after cranial radiation for acute lymphocytic leukemia.

Purpose: To describe the ophthalmic findings of cranial radiation-induced orbital meningioma after acute lymphocytic leukemia therapy.

Methods: This is a prospective clinical report.

Results: We describe two patients recently evaluated with orbital meningiomas many years after cranial radiation for acute lymphocytic leukemia.