Publications by authors named "M J Schuemie"
Article Synopsis
- This study compares the cardiovascular effectiveness of different second-line antihyperglycemic agents (SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas) in patients with type 2 diabetes and cardiovascular disease.
- Using data from over 1.4 million patients across multiple databases, the researchers analyzed the risk of major adverse cardiovascular events (MACE) over a follow-up period of several years.
- Results indicated that SGLT2 inhibitors and GLP-1 receptor agonists had significantly lower risks of MACE compared to DPP-4 inhibitors and sulfonylureas, pointing to their potential superiority as treatment options for
Article Synopsis
- Large-scale observational health databases are increasingly used for studying the effectiveness and safety of medical products but face computing challenges due to the large number of patients.
- The paper introduces the use of graphics processing units (GPUs) to speed up survival regression model calculations, specifically Cox and Fine-Gray models, through advanced parallel scan algorithms.
- The authors demonstrate that using GPUs significantly accelerates the analysis process, allowing researchers to efficiently handle studies with millions of patients and making their methods available through the open-source R package Cyclops.
Propensity score adjustment addresses confounding by balancing covariates in subject treatment groups through matching, stratification, inverse probability weighting, etc. Diagnostics ensure that the adjustment has been effective. A common technique is to check whether the standardized mean difference for each relevant covariate is less than a threshold like 0.
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- Previous research showed better safety and effectiveness outcomes for thiazides compared to ACE inhibitors (ACEi), but allowed addition of a second medication after a week.
- In this study, the definition of monotherapy was changed, requiring participants to exit if they started another antihypertensive medication.
- The results demonstrated that the significant differences in effectiveness were no longer present, although thiazides still had a more favorable safety profile.