Publications by authors named "M J Schofield"
The Academy of Nutrition and Dietetics' Telehealth Task Force was charged with developing a telehealth policy stance to guide the work of the Academy. The task force comprised representatives from diverse areas of telehealth practice, including research, practice, payment, and licensure. They convened in 2020-2021 to conduct an environmental scan and develop a recommended stance on telehealth policy.
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- Professional pitchers often experience anterior shoulder pain, which may relate to a smaller coracohumeral distance (CHD) and disorganization of the subscapularis tendon, particularly in their dominant arm.
- The study hypothesized that pitcher's dominant arm would show these adaptations compared to the nondominant arm and that humeral retroversion (HR) would relate to both CHD and tendon organization.
- Results indicated that the dominant arm had a significantly narrower CHD, more scapular protraction, and greater tendon disorganization than the nondominant arm, with HR influencing these factors.
Factors Precipitating Overnight Admission After Sialolithectomy.
Otolaryngol Head Neck Surg
November 2024
Objective: To determine factors predicting overnight admission after sialolithectomy.
Study Design: Quality outcome database research.
Setting: The National Surgical Quality Improvement Program American College of Surgeons Participant User Files.
Membrane chromatography for AAV full capsid enrichment: Process development to scale up.
J Chromatogr B Analyt Technol Biomed Life Sci
August 2024
The recent FDA approval of several adeno-associated virus (AAV)-based gene therapies is driving demand for AAV production. One of the biggest AAV manufacturing challenges is removing "empty" capsids, which do not contain the gene of interest. Anion exchange chromatography has emerged as the leading solution for scalable full capsid enrichment.
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- Actin plays a crucial role in maintaining the chondrocyte phenotype, but monolayer expansion for cell-based therapies causes chondrocytes to dedifferentiate, altering their actin structure and reducing cartilage matrix expression.* -
- This study focuses on the roles of tropomyosin (TPM3.1) and RhoGTPase (CDC42) in regulating F-actin networks and chondrocyte phenotype during dedifferentiation and passaging.* -
- Results show that inhibiting TPM3.1 or CDC42 leads to reorganization of F-actin back to a more differentiated state, indicated by reduced fibroblastic matrix expression and increased expression of chondrogenic factors like SO