Publications by authors named "M J Sauer"
Recent research has concentrated on the development of suitable in vitro cell models for the early identification of hepatotoxicity during drug development in order to reduce the number of animal models and to obtain a better predictability for hepatotoxic reactions in humans. The aim of the presented study was to identify translational biomarkers for acute liver injury in human patients that can serve as biomarkers for hepatocellular injury in vivo and in vitro in simple cell models. Therefore, 188 different metabolites from patients with acute-on-chronic liver failure before and after liver transplantation were analyzed with mass spectrometry.
View Article and Find Full Text PDFBackground: Energy storing and return (ESAR) prosthetic feet often provide high energy return at the cost of increased foot height, compromised appearance, and reduced flexibility. An ESAR foot, Ottobock Evanto, with a novel compact design has been introduced (novel foot).
Objective: To characterize user preference and benefits of a novel foot compared with the subject's previously worn (everyday foot) and comparator foot, Össur Pro-Flex XC.
Article Synopsis
- This research focuses on a specific yeast known for its ability to adapt and produce various products from different carbon sources while existing in either planktonic (free-floating) or biofilm states.
- The study compares the metabolic activities of the yeast in both states, using traditional stirred tank bioreactors for planktonic cultivation and trickle bed bioreactors for biofilm cultivation.
- Results show that although biofilm cultivation has lower overall productivity, the production rate remains steady, highlighting its potential for continuous production processes when supplied with enriched oxygen.
Betibeglogene autotemcel gene therapy in patients with transfusion-dependent, severe genotype β-thalassaemia (HGB-212): a non-randomised, multicentre, single-arm, open-label, single-dose, phase 3 trial.
Lancet
November 2024
Background: Transfusion-dependent β-thalassaemia (TDT) is a severe disease, resulting in lifelong blood transfusions, iron overload, and associated complications. Betibeglogene autotemcel (beti-cel) gene therapy uses autologous haematopoietic stem and progenitor cells (HSPCs) transduced with BB305 lentiviral vector to enable transfusion independence.
Methods: HGB-212 was a non-randomised, multicentre, single-arm, open-label, phase 3 study of beti-cel in patients with TDT conducted at eight centres in France, Germany, Greece, Italy, the UK, and the USA.
Article Synopsis
- Veterans face higher rates of chronic pain and opioid prescriptions, prompting organizations like the CDC and DoD to recommend naloxone for at-risk patients.
- An interprofessional team implemented a project at a VA clinic to increase naloxone coprescriptions by utilizing the Opioid Therapy Risk Report to identify eligible patients.
- The initiative successfully raised naloxone coprescription rates from 42% to 82% over a year, showcasing the effectiveness of provider notifications for high-risk patients.