Publications by authors named "M J Ruiz-Hidalgo"
Article Synopsis
- * In experiments, dinaciclib increased the sensitivity of certain cancer cell lines to radiation but did not significantly affect apoptosis levels or alter certain cellular signaling pathways, suggesting a complex interaction between the drug and radiation.
- * The study highlights how dinaciclib's inhibition of CDK12 leads to reduced BRCA1 levels, which affects DNA repair mechanisms and may contribute to cancer cell aging, proposing a potential personalized treatment approach based on the genetic characteristics of different tumors.
Article Synopsis
- Aromatase inhibitors (AIs) like Letrozole are gaining attention for treating hormone-dependent cancers, but they can cause side effects like hot flashes and fibromyalgia while posing risks such as endometrial cancer.
- New AI derivatives inspired by Letrozole have been developed, particularly one with a benzimidazole ring (compound 6), which shows better aromatase inhibitory activity and reduces cancer cell growth compared to established AIs.
- Compound 6 enhances binding to the aromatase enzyme due to its ferrocene structure, leading to improved interaction and increased effectiveness in inhibiting cancer cell proliferation.
Background And Purpose: MAPKs are among the most relevant signalling pathways involved in coordinating cell responses to different stimuli. This group includes p38MAPKs, constituted by 4 different proteins with a high sequence homology: MAPK14 (p38α), MAPK11 (p38β), MAPK12 (p38γ) and MAPK13 (p38δ). Despite their high similarity, each member shows unique expression patterns and even exclusive functions.
View Article and Find Full Text PDFSarcomas constitute a heterogeneous group of rare and difficult-to-treat tumors that can affect people of all ages, representing one of the most common forms of cancer in childhood and adolescence. Little is known about the molecular entities involved in sarcomagenesis. Therefore, the identification of processes that lead to the development of the disease may uncover novel therapeutic opportunities.
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- Over the past 30 years, research on how cells respond to ionizing radiation (IR) has significantly expanded, particularly focusing on the p38 MAPK signaling pathway.
- p38 MAPK is activated by IR and is involved in crucial cellular processes like cell cycle regulation, apoptosis, and senescence, but its exact role in determining radioresistance or sensitivity remains unclear.
- This review aims to summarize what we know about the p38 MAPK family in the context of IR, including their involvement in REDOX control, fibrosis, and the potential to enhance radiotherapy effects through specific compounds.