Publications by authors named "M J Redondo"
Aims/hypothesis: Many studies of type 1 diabetes pathogenesis focus on individuals with high-risk HLA haplotypes. We tested the hypothesis that, among islet autoantibody-positive individuals, lacking HLA-DRB1*04-DQA1*03-DQB1*0302 (HLA-DR4-DQ8) and/or HLA-DRB1*0301-DQA1*0501-DQB1*0201 (HLA-DR3-DQ2) is associated with phenotypic differences, compared with those who have these high-risk HLA haplotypes.
Methods: We classified autoantibody-positive relatives of individuals with type 1 diabetes into four groups based on having both HLA-DR4-DQ8 and HLA-DR3-DQ2 (DR3/DR4; n=1263), HLA-DR4-DQ8 but not HLA-DR3-DQ2 (DR4/non-DR3; n=2340), HLA-DR3-DQ2 but not HLA-DR4-DQ8 (DR3/non-DR4; n=1607) and neither HLA-DR3-DQ2 nor HLA-DR4-DQ8 (DRX/DRX; n=1294).
Article Synopsis
- Insulin resistance is an important factor in the early stages of type 1 diabetes (T1D) risk, and the study looks at its genetic, metabolic, and immune aspects among at-risk individuals.
- Researchers divided relatives of T1D patients into high and low insulin resistance groups and assessed their genetic risk, glucose control, metabolic hormones, and immune cell profiles.
- The high insulin resistance group showed metabolic changes like increased insulin levels and a unique immune cell profile with more insulin-specific CD8 T cells, suggesting a link between insulin resistance and immune responses in T1D susceptibility.
Objectives: Type 1 diabetes mellitus (T1D) is a heterogeneous condition. We aimed to study the associations between age and sex with clinical characteristics at the onset of pediatric T1D.
Methods: A secondary analysis was conducted on data collected retrospectively from 706 children newly diagnosed with T1D at a large tertiary hospital in southeastern USA.
Introduction: There are no established methods to identify children with atypical diabetes for further study. We aimed to develop strategies to systematically ascertain cases of atypical pediatric diabetes using electronic medical records (EMR).
Research Design And Methods: We tested two strategies in a large pediatric hospital in the USA.