Development and Validation of Machine Learning Model Platelet Index-based Predictor for Colorectal Cancer Stage.

Introduction: Colorectal cancer (CRC) staging is essential for effective treatment planning and prognosis. While platelet indices have shown promise in indicating CRC aggressiveness, a platelet index-based predictor for CRC staging has not been established in Indonesia. This study aimed to explore the relationship between platelet indices and CRC stage and to develop a predictive model and application.

Metabolomics and Anticancer Potential of the Aerial Parts of Dryopteris ramosa against Cancerous Cell Lines Assisted with Advanced Computational Approaches.

Introduction: Dryopteris ramosa is a high-altitude plant of moist and shady habitat. Its aerial parts are edible and orally administered as an antibiotic and effective aphrodisiac. They are also used as pesticides, astringents, and febrifuges.

Novel Dynamic Organ Storage System Enhances Liver Graft Function in a Porcine Donation After Circulatory Death Model.

Donation after circulatory death (DCD) livers face increased risks of critical complications when preserved with static cold storage (SCS). Although machine perfusion (MP) may mitigate these risks, its cost and logistical complexity limit widespread application. We developed the Dynamic Organ Storage System (DOSS), which delivers oxygenated perfusate at 10°C with minimal electrical power requirement and allows real-time effluent sampling in a portable cooler.

Extensive Myocardial Calcification Rapidly Progressing After Orthotopic Liver Transplantation.

Orthotopic liver transplantation has been rarely associated with myocardial calcification; no prior cases of asymptomatic calcification have been documented. We present the unique finding of asymptomatic myocardial calcification following orthotopic liver transplantation.