Publications by authors named "M J RENNER"
Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 gene. We have designed a dual adeno-associated viral vector encoding a split-intein adenine base editor to correct the most common mutation in ABCA4 (c.5882G>A, p.
View Article and Find Full Text PDFThe dimension of a quantum state is traditionally seen as the number of superposed distinguishable states in a given basis. We propose an absolute, i.e.
View Article and Find Full Text PDFArticle Synopsis
- Histology is crucial for examining tissue structure and cell details, but standard methods for cryosectioning small tissues like organoids lack efficiency and cost-effectiveness, hindering analysis.
- The adapted HistoBrick method uses an optimal embedding mixture of 8% PEGDA and 2.5% gelatine, providing support for fragile samples during cryosectioning and preserving delicate structures of human retinal organoids.
- Using these PEGDA-gelatine HistoBricks, researchers monitored retinal organoid development over time, finding that photoreceptor cell bodies were sustained for up to 98 weeks, although outer segments diminished, making this approach valuable for increased throughput in tissue studies and research.
Recent marine heatwaves have had pervasive effects on marine ecosystems, from declines in primary production to die-offs of top predators. Seabird mortalities are often observed in association with heatwaves, but population impacts are not well understood. In this work, we report the rapid mortality of approximately half of Alaska's common murre () population in response to an extreme marine heatwave.
View Article and Find Full Text PDFContext: The anterior cruciate ligament (ACL) is well researched since injuries typically result in lengthy recoveries and rehabilitation periods until athletes can return to full activity. Although a large body of literature on the early and late stages of rehabilitation following ACL reconstructive (ACLR) surgery exists, less is known regarding the mid-phase of ACL rehabilitation and healthy versus injured limb differences in functional testing during this stage.
Objectives: The purpose of this study is to determine if Y-Balance Test (YBT) scores obtained during the mid-phase of ACLR rehabilitation change over months 4, 5, and 6.