Publications by authors named "M J Prest"
Background: Human Platelet Lysate (hPL) is a platelet-derived and growth factor-rich supplement for cell culture. It can be prepared from surplus platelet concentrates initially intended for transfusion. Amotosalen-based photochemical pathogen inactivation of platelet concentrates is used in a number of blood establishments worldwide to minimize the risk of pathogen transmission from donor to patient.
View Article and Find Full Text PDFObjective: In the U.S., uterine cancer incidence is rising, with racial and ethnic minorities experiencing the largest increases.
View Article and Find Full Text PDFBackground: Contrary to clinical guidelines, there has been a decrease over time in estrogen therapy use in premenopausal women undergoing bilateral oophorectomy for benign indications.
Objective: This study aimed to estimate the excess morbidity and mortality associated with current patterns of estrogen therapy use in women who undergo bilateral oophorectomy with hysterectomy for benign indications.
Study Design: We developed 2 Bayesian sampling Markov state-transition models to estimate the excess disease incidence (incidence model) and mortality (mortality model).
Article Synopsis
- Early detection of cancer, including pancreatic ductal adenocarcinoma (PDAC), can have significant benefits, but these depend on factors like cancer type and screening effectiveness.
- Research in this study used a population model to simulate PDAC progression and aimed to understand the optimal timing for early detection to maximize mortality benefits.
- The findings suggest that detecting PDAC 4-6 years before clinical diagnosis yields the greatest life-years gained, but benefits decrease if detection happens too early or too late based on the speed of cancer progression.