Publications by authors named "M J Polyak"
Currently there are few antibacterial dosage regimens established to be safe and effective for sea turtles. Pharmacokinetic evaluation of antibiotics is an essential step in establishing accurate dosage guidelines for a particular species. Metronidazole is an antibiotic that is effective against anaerobic bacteria and some protozoa.
View Article and Find Full Text PDFConventional dendritic cells (cDCs) generate protective cytotoxic T lymphocyte (CTL) responses against extracellular pathogens and tumors. This is achieved through a process known as cross-presentation (XP), and, despite its biological importance, the mechanism(s) driving XP remains unclear. Here, we show that a cDC-specific pore-forming protein called apolipoprotein L 7C (APOL7C) is up-regulated in response to innate immune stimuli and is recruited to phagosomes.
View Article and Find Full Text PDFThis study evaluates the accuracy and repeatability of craniofacial measurements with a 3D light scanner, specifically the EINSTAR scanner, in comparison to traditional caliper measurements for facial anthropometry. Eleven volunteers were assessed by two examiners, one experienced and one inexperienced, who performed direct caliper measurements and indirect measurements using the scanner. Results indicated minimal differences between caliper and scanner results, with overall high accuracy and reliability demonstrated by correlation coefficients.
View Article and Find Full Text PDFArticle Synopsis
- - CCDC88B is linked to chronic inflammatory diseases and impacts dendritic cell (DC) migration in mice; disrupting this gene results in defective DC movement.
- - Researchers found that the proteins ARHGEF2 and RASAL3 interact with CCDC88B and influence neuroinflammation and colitis susceptibility in mice with mutations in these proteins.
- - The CCDC88B/RASAL3/ARHGEF2 complex regulates DC migration by affecting RHOA activation, with ARHGEF2 and RASAL3 having opposing effects on cell movement.
Objectives: The study aimed to compare the antibacterial effect of a novel disinfectant, hyper-pure chlorine dioxide (hClO) to sodium hypochlorite (NaOCl) in various depths of dentin tubules.
Materials And Methods: The distal root of the extracted lower molars was infected artificially with Enterococcus faecalis. The control group was rinsed with saline, and the test groups were irrigated with either 5% NaOCl or 0.