[Oligoastrocytoma with signet-ring cell differentiation. A morphological, ultrastructural and immunohistochemical study].

We present a case of a mixed glial tumor (oligoastrocytoma) with signet-ring cells. This cellular feature is a rare differentiation in glial tumors of the central nervous system. Histological, immunohistochemical and ultrastructural findings have been analyzed.

Histologically benign metastatic meningioma: morphological and cytogenetic study. Case report.

The authors report on a 75-year-old man with histologically benign fibroblastic meningioma metastasizing to the lung, liver, spleen, and kidney. The original tumor exhibited a complex karyotype involving different structural and numerical anomalies associated with monosomy of chromosome 22. The implication of chromosome 1p36 was confirmed by fluorescence in situ hybridization in most interphase nuclei.

[Monosomy 1p and alkaline phosphatase in meningiomas. Citopathological, histochemical and genetical study in 10 tumors].

Background: Cytogenetic studies in meningiomas show that 1p monosomy constitutes an important factor involved in their progression. Genes coding for unspecific alkaline phosphatase (AP-un) are located in this chromosome, in particular in 1p34-p36.1.

Trabecular trajectory in the articular processes of the human fourth cervical vertebra.

The articular processes (AP) of the neural arch have been implicated in weight transmission through the cervical spine. To analyse the mechanism of weight transmission in the AP, we studied the direction of forces within it, in particular, the pattern of trabecular trajectories. Twenty-two AP from C4 vertebrae were studied in anatomical sections, and corresponding photoelastic models from selected sections were constructed and analysed.

Histopathological and cytogenetic findings in benign, atypical and anaplastic human meningiomas: a study of 60 tumors.

Meningiomas may display benign (grade I), atypical (grade II) and anaplastic (grade III) histopathological findings. The cytogenetic studies strongly suggest that secondary changes (beyond loss of chromosome 22) appear to be associated with more atypical features and with greater clinical aggressivity. We studied 60 tumors from 52 patients.