Publications by authors named "M J Perchinsky"
Objectives: To evaluate whether warfarin targeted at an international normalized ratio of 1.8 (range, 1.5-2.
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- A study aimed to determine if targeting a lower INR of 1.8 (range 1.5-2.0) for warfarin is safe for patients with an On-X aortic mechanical valve, alongside daily aspirin.
- Researchers tracked 510 patients over an average of 3.4 years, comparing outcomes with those from a prior trial using standard warfarin dosing (INR 2.0-3.0).
- Results showed a significant reduction in adverse events like thromboembolism and major bleeding, indicating that the lower INR approach could be both safe and effective in this patient group.
Background: The purpose of this study was 3-fold: to compare the quality of life (QOL) in age- and sex-matched patients who received biological and mechanical prosthetic valves in isolated aortic valve replacement, to compare the QOL of patients with aortic valve replacement with the general population, and to compare patients with biological and mechanical prostheses with certain valve-specific questions and relate these responses to overall QOL.
Methods And Results: Patient-perceived QOL was evaluated in 200 patients who were sampled from a population of 420 patients (age range 51 to 65 years) who underwent isolated aortic valve replacement in the period of 1986 to 1996. One hundred of the sampled patients had a mechanical valve inserted and an equal number had porcine bioprostheses.
Background: Primary cardiac tumors are infrequent, and few cardiac surgeons have extensive experience in treating them. The majority of the tumors are benign. As noninvasive diagnostic imaging of cardiac masses continues to improve, the number of these tumors that are seen by clinicians will increase.
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