Motor, mood, and memory impairments persist during remission periods in chronic colitis and are influenced by neuroinflammation and sex.

Ulcerative colitis is a chronic pathology characterized by relapsing-remitting phases of intestinal inflammation. Additionally, some patients develop neuropsychiatric disorders, such as depression and anxiety, or cognitive deficits. We aimed to investigate whether the development of chronic colitis elicits memory, locomotion, and mood impairments.

Establishing a Method of Systematic and Reliable Analysis of Psychodynamic Process Notes.

Process notes contain unique information concerning core elements of a psychodynamic treatment. These elements may be both conscious and unconscious for the author. One element for study is the tendency to which a therapist writes about providing either supportive or expressive interventions.

Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain.

Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons.

Methods: We have analysed the gut and the ventral midbrain from subjects previously diagnosed with IBD and form a DSS-based rat model of gut inflammation in terms of α-syn pathology.

Hot carbonates deep within the Chicxulub impact structure.

Constraining the thermodynamic conditions within an impact structure during and after hypervelocity impacts is extremely challenging due to the transient thermal regimes. This work uses carbonate clumped-isotope thermometry to reconstruct absolute temperatures of impact lithologies within and close to the ∼66 Myr old Chicxulub crater (Yucatán, México). We present stable oxygen (δO), carbon (δC), and clumped-isotope (Δ) data for carbonate-bearing impact breccias, impact melt rock, and target lithologies from four drill cores on a transect through the Chicxulub structure from the northern peak ring to the southern proximal ejecta blanket.

Using Collaborative Documentation to Support Person-Centered Care in Substance Use Settings.

The delivery of person-centered care (PCC) is critical to promoting service engagement among individuals who use substances. Collaborative documentation (CD) is an emerging person-centered practice used in community mental health, but has not been evaluated in substance use settings. This qualitative study conducted focus groups with substance use treatment providers (n=22) in an outpatient clinic to examine the impact of CD on PCC and clinical quality.