Publications by authors named "M J Ngama"
Article Synopsis
- The study aimed to assess how different dosing regimens of ivermectin affect the survival of malaria vectors (mosquitoes) and their potential to reduce malaria transmission.
- An open-label randomized control trial was conducted in Kenya with 36 participants, comparing a single dose of ivermectin, a 3-day regimen of ivermectin, albendazole, and a control group with no treatment.
- Results indicated that both ivermectin regimens significantly impacted mosquito survival within the first week, but the single dose proved to be more effective over a 10-day period compared to the multi-day regimen.
[A global core outcome measurement set for snakebite clinical trials].
Med Trop Sante Int
September 2023
Background: Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation.
Method: A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials.
A global core outcome measurement set for snakebite clinical trials.
Lancet Glob Health
February 2023
Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials.
View Article and Find Full Text PDFIntroduction: The high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs in low- and middle-income countries (LMICs). The PROUD (Preventing RespiratOry syncytial virUs in unDerdeveloped countries) Taskforce of 24 RSV worldwide experts assessed key needs for RSV prevention in LMICs, including vaccine and newer preventive measures.
Methods: A global, survey-based study was undertaken in 2021.
Article Synopsis
- Snakebites impact over 5 million people annually, leading to over 100,000 deaths, with antivenom being the primary but problematic treatment due to its high cost and adverse effects.
- Unithiol, a chelating agent used for heavy metal poisoning, has shown promise in preventing tissue damage from certain viper species in small animal studies, prompting a clinical trial for snakebite treatment repurposing.
- The phase I trial will evaluate the safety of escalating doses of unithiol in 64 healthy volunteers, focusing on dose response, adverse effects, and pharmacokinetics, with the potential to offer a safer, orally-administered alternative to traditional antivenom.