Publications by authors named "M J Nemeth"
More than three billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here we show that language models trained at scale on evolutionary data can generate functional proteins that are far away from known proteins. We present ESM3, a frontier multimodal generative language model that reasons over the sequence, structure, and function of proteins.
View Article and Find Full Text PDFGiven that perioperative normothermia represents a quality parameter in pediatric anesthesia, numerous studies have been conducted on temperature measurement, albeit with heterogeneous measurement intervals, ranging from 30 s to fifteen minutes. We aimed to determine the minimum time interval for reporting of intraoperative core body temperature across commonly used measurement intervals in children. Data were extracted from the records of 65 children who had participated in another clinical study and analyzed using a quasibinomial mixed linear model.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses the challenges of analyzing survey data from clinical trials, particularly dealing with subjective measures like well-being or pain, which typically use limited discrete response options.
- It critiques the common use of ordinary linear regression for such data, as it may violate key assumptions, potentially leading to biased predictions and insights focused only on average responses.
- The authors advocate for ordinal regression models, which better handle the nature of the data by providing probabilistic estimates across all response categories and discuss their application, strengths, and limitations in a pediatric anesthesia context.
No need to execute: Omitted responses still yield response-response binding effects.
J Exp Psychol Hum Percept Perform
December 2024
In the literature on human action control, the binding and retrieval of responses are assumed to shape the coordination of more complex actions. Specifically, the consecutive execution of two responses is assumed to result in their integration into cognitive representations (so-called event files) and can be retrieved from that upon later response repetition, thereby influencing behavior. Against the background of ideomotor theory and more recent theorizing in the binding and retrieval in action control framework (Frings et al.
View Article and Find Full Text PDFBackground: Collaborations are an essential element of scientific activity and particularly important in fields such as pediatric anesthesiology, where the evidence base in general is relatively limited. A recent scientometric analysis revealed a geographic diversification of publication activity in pediatric anesthesiology within the last two decades, accompanied by a surge in international collaborations.
Objectives: Given the hypothesis of a similar growth in the activity and dynamics of publications in pediatric anesthesiology, the objective of this scientometric study was to analyze the publication activity and collaboration habits in research in pediatric anesthesiology from Germany, Austria and Switzerland (D-A-CH).