Neuroprotective Effects of Metformin in Stroke Patients: A Systematic Review and Meta-analysis of Cohort Studies.

Objectives: People with diabetes are 1.5 times more likely to experience stroke than those without diabetes, underlining the urgent need to address this issue. Metformin is often the initial medication chosen to manage diabetes mellitus (DM).

Multi-component reactions in protein modification and immobilization.

Protein modification/immobilization has been introduced as a large toolbox for creating a myriad of engineered proteins with profound implications for various scientific and industrial applications. Proteins immobilization techniques are generally performed through protein fixation in/to heterogeneous materials or via inter cross-linking of protein molecules, enabling the development of biocatalysts, biosensors, and drug delivery systems. On the other hand, chemical modification of proteins offers tailored changes in their functionality, enhances protein performance, extends their shelf life, and enables their specific binding interactions.

Global Prevalence of Excessive Daytime Sleepiness in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.

The prevalence of obstructive sleep apnea (OSA) has increased worldwide in recent years, becoming a significant public health concern. One of the most important complications experienced by individuals with OSA is excessive daytime sleepiness (EDS). This study aims to investigate the prevalence of EDS in patients with OSA through a systematic review and meta-analysis.

Intermolecular interaction of AlO oxymetallic clusters in the detection of atmospheric pollutants: a DFT exploration of CO, CO, H, N, NO, NO, O, and SO, binding mechanisms.

Due to the lack of inherent geometric symmetry present in the structures of aluminum oxide clusters, determining their stable configuration becomes an exceedingly formidable task computationally. In this comprehensive analysis, we first propose the most stable state of AlO, determined through Density Functional Theory calculations at ωB97XD/Def2-TZVP level of theory. Multiple structural isomers were scrutinized for their stability and spin state, with the optimal structure determined using the bee colony algorithm for global optimization.

From Conventional Detection to Point-of-care Tests (POCT) Method for Pediatric Respiratory Infections Diagnosis: A Systematic Review.

Bacterial respiratory infections pose significant health risks to children, particularly infants susceptible to upper respiratory tract infections (URTIs). The COVID-19 pandemic has further exacerbated the prevalence of these infections, with pathogens such as and commonly implicated in pediatric cases. The critical need for accurate and timely detection of these bacterial agents has highlighted the importance of advanced diagnostic techniques, including multiplex real-time PCR, in clinical practice.