Publications by authors named "M J McQueen"
Purpose: Paediatric patients with heart failure requiring ventricular assist devices are at heightened risk of neurologic injury and psychosocial adjustment challenges, resulting in a need for neurodevelopmental and psychosocial support following device placement. Through a descriptive survey developed in collaboration by the Advanced Cardiac Therapies Improving Outcomes Network and the Cardiac Neurodevelopmental Outcome Collaborative, the present study aimed to characterise current neurodevelopmental and psychosocial care practices for paediatric patients with ventricular assist devices.
Method: Members of both learning networks developed a 25-item electronic survey assessing neurodevelopmental and psychosocial care practices specific to paediatric ventricular assist device patients.
Article Synopsis
- Learning Health Networks (LHNs) have recently been integrated into transplantation, building on their two-decade evolution in medicine.
- This paper reviews three LHNs focused on end-stage organ disease and their ability to adapt quickly to challenges, particularly during the COVID-19 pandemic.
- Key aspects include the importance of patient and family engagement, collaboration with Transplant Families, common challenges faced, and how LHNs can enhance knowledge sharing to improve pediatric transplantation outcomes.
Background: Pegfilgrastim-cbqv/CHS-1701 (UDENYCA) (hereafter referred to as pegfilgrastim-cbqv) was approved in 2018 by the US Food and Drug Administration as a biosimilar for pegfilgrastim (Neulasta) (hereafter referred to as pegfilgrastim). Both pegfilgrastim-cbqv and pegfilgrastim are conjugates of recombinant human granulocyte colony stimulating factor (r-metHuG-CSF) with a 20 kDa polyethylene glycol (PEG) indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients receiving myelosuppressive anticancer drugs. The demonstration of analytical similarity for PEG-protein conjugates presents unique challenges since both the protein and PEG attributes must be characterized.
View Article and Find Full Text PDFIntroduction: The Research Program (Program) is an ongoing epidemiologic cohort study focused on collecting lifestyle, health, socioeconomic, environmental, and biological data from 1 million US-based participants. The Program has a focus on enrolling populations that are underrepresented in biomedical research (UBR). Federally Qualified Health Centers (FQHCs) are a key recruitment stream of UBR participants.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to find clinical and biochemical indicators that can point out individuals with dysglycaemia (diabetes/pre-diabetes) who do not experience serious health issues during follow-up.
- Researchers analyzed data from the ORIGIN study involving over 12,500 adults to determine factors linked to remaining free from major health outcomes over a median follow-up of 6.2 years.
- Key findings showed that younger age, female sex, and specific clinical and biomarker profiles can effectively identify individuals with prediabetes or early type 2 diabetes who are least likely to face serious health complications.