Publications by authors named "M J McGann"

Trends and developments in recent behavioural and cognitive sciences demonstrate the need for a well-developed theoretical and empirical framework for examining the ecology of human behaviour. The increasing recognition of the role of the environment and interaction with the environment in the organization of behaviour within the cognitive sciences has not been met with an equally disciplined and systematic account of that environment (Heft 2018 . , 99-123 (doi:10.

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Reorienting psychological science.

Philos Trans R Soc Lond B Biol Sci

August 2024

Psychological phenomena occur across a wide range of scales, ranging from small, quick events of neurology and biology, to broader, more prolonged unfoldings typical of extended cultural practices. Although theories deployed by psychologists of different stripes have tended to incorporate these different scales, this is typically done in a manner that is implicit, and often unsystematic. That is, typical psychological research is conducted in a manner that is 'scale-blind'.

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BCMA-directed chimeric antigen receptor T-cell (CAR T) therapies, including idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel), have transformed the treatment landscape for relapsed-refractory multiple myeloma (RRMM), offering remarkable efficacy with hallmark toxicity risks of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). The FDA mandates a 4-week monitoring period at the treatment center as part of a Risk Evaluation and Mitigation Strategy (REMS) to monitor and manage these toxicities, which, while prudent, may add unnecessary challenges related to access and socioeconomic disparities. We sought to assess CRS and ICANS onset and duration, as well as causes of non-relapse mortality (NRM) in real-world BCMA CAR T recipients in order to better inform future changes to the monitoring guidelines for CAR T recipients.

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Article Synopsis
  • High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation is the go-to treatment for newly diagnosed multiple myeloma patients, leading to better survival rates.
  • Current methods for mobilizing stem cells include using G-CSF alone or with plerixafor; motixafortide is a new option approved for use with G-CSF.
  • Although motixafortide shows better pharmacokinetics than plerixafor, their effectiveness is similar in trials, and motixafortide's higher cost and more demanding administration may limit its use in practice.
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