Philos Trans R Soc Lond B Biol Sci
September 2024
Trends and developments in recent behavioural and cognitive sciences demonstrate the need for a well-developed theoretical and empirical framework for examining the ecology of human behaviour. The increasing recognition of the role of the environment and interaction with the environment in the organization of behaviour within the cognitive sciences has not been met with an equally disciplined and systematic account of that environment (Heft 2018 . , 99-123 (doi:10.
View Article and Find Full Text PDFPsychological phenomena occur across a wide range of scales, ranging from small, quick events of neurology and biology, to broader, more prolonged unfoldings typical of extended cultural practices. Although theories deployed by psychologists of different stripes have tended to incorporate these different scales, this is typically done in a manner that is implicit, and often unsystematic. That is, typical psychological research is conducted in a manner that is 'scale-blind'.
View Article and Find Full Text PDFTransplant Cell Ther
September 2024
BCMA-directed chimeric antigen receptor T-cell (CAR T) therapies, including idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel), have transformed the treatment landscape for relapsed-refractory multiple myeloma (RRMM), offering remarkable efficacy with hallmark toxicity risks of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). The FDA mandates a 4-week monitoring period at the treatment center as part of a Risk Evaluation and Mitigation Strategy (REMS) to monitor and manage these toxicities, which, while prudent, may add unnecessary challenges related to access and socioeconomic disparities. We sought to assess CRS and ICANS onset and duration, as well as causes of non-relapse mortality (NRM) in real-world BCMA CAR T recipients in order to better inform future changes to the monitoring guidelines for CAR T recipients.
View Article and Find Full Text PDFJ Oncol Pharm Pract
September 2024