Publications by authors named "M J Maeder"
Background: Hypersensitivity reaction is a rare side effect during immunosuppressive treatment with azathioprine (AZA). Some cases of cardiac involvement have already been reported but causality is notoriously difficult to prove.
Case Summary: We present the case of a 68-year-old man with two episodes of reversible left ventricular (LV) dysfunction.
Thyroid dysfunction is associated with characteristic changes in heart rate and arrhythmias. Thyroid hormones act through genomic and non-genomic effects on myocytes and influence contractility, relaxation and action potential duration through a variety of mechanisms. Atrial fibrillation is the most common arrhythmia associated with thyroid dysfunction, it occurs in both euthyroidism and hyperthyroidism in clear association with T4 levels.
View Article and Find Full Text PDFAims: With the 2022 pulmonary hypertension (PH) definition, the mean pulmonary artery pressure (mPAP) threshold for any PH was lowered from ≥25 to >20 mmHg, and the pulmonary vascular resistance (PVR) value to differentiate between isolated post-capillary PH (IpcPH) and combined pre- and post-capillary PH (CpcPH) was reduced from >3 Wood units (WU) to >2 WU. We assessed the impact of this change in the PH definition in aortic stenosis (AS) patients undergoing aortic valve replacement (AVR).
Methods And Results: Severe AS patients ( = 503) undergoing pre-AVR cardiac heart catheterization were classified according to both the 2015 and 2022 definitions.
Article Synopsis
- * Among 1,152 patients studied, those with normotensive acute heart failure exhibited significantly higher levels of hemodynamic stress and heart cell injury markers compared to those who were hypertensive.
- * The findings indicated that normotensive patients had a higher risk of mortality, particularly if their biomarker levels were elevated, which was confirmed in a separate cohort of 324 patients.