Publications by authors named "M J M de Rooij"
Systems biology tackles the challenge of understanding the high complexity in the internal regulation of homeostasis in the human body through mathematical modelling. These models can aid in the discovery of disease mechanisms and potential drug targets. However, on one hand the development and validation of knowledge-based mechanistic models is time-consuming and does not scale well with increasing features in medical data.
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- Chronic subdural hematoma (CSDH) treatment often involves burr-hole drainage and either subdural or subgaleal drain insertion, with surgeon preference influencing the choice.
- A study analyzed 700 CSDH cases from 2017 to 2022, finding no significant differences in recurrence, reoperation rates, or complications between subdural and subgaleal drains.
- The results suggest that both drainage methods are equally effective, indicating a need for a larger, multicenter randomized controlled trial to further explore their outcomes.
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- Ticks are common in North-East Italy and can carry zoonotic pathogens that affect public health.
- A study collected ticks from 26 sites between 2015-2021 to analyze their habitat and the presence of these pathogens through PCR tests.
- The research identified hotspots for pathogen presence linked to environmental factors like temperature, rainfall, altitude, and vegetation, providing valuable insights for public health risk management.
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- Biparametric MRI (bpMRI) may serve as a valid alternative to multiparametric MRI (mpMRI) for diagnosing clinically significant prostate cancer (csPCa), as assessed in a large international observer study.
- The study involved 400 mpMRI examinations from four different European centers, where readers evaluated both bpMRI and mpMRI for their ability to accurately diagnose csPCa, finding them to be similarly effective.
- Key findings indicated that bpMRI and mpMRI had comparable diagnostic accuracy (AUROC values) and sensitivity, with bpMRI showing a noninferior performance, though both methods had similar specificity when distinguishing csPCa.
BackgroundOutbreaks of highly pathogenic avian influenza (HPAI) on poultry farms and in wild birds worldwide persists despite intensified control measures. It causes unprecedented mortality in bird populations and is increasingly affecting mammalian species. Better understanding of HPAI introduction pathways into farms are needed for targeted disease prevention and control.
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