Publications by authors named "M J Lucarelli"
Alcohol is the second-most misused substance after tobacco. It has been identified as a causal factor in more than 200 diseases and 5.3% of all deaths and is associated with significant behavioral, social, and economic difficulties.
View Article and Find Full Text PDFAlcohol consumption has been consistently linked to an increased risk of several cancers, including breast and ovarian cancer. Despite substantial evidence supporting this association, the precise mechanisms underlying alcohol's contribution to cancer pathogenesis remain incompletely understood. This narrative review focuses on the key current literature on the biological pathways through which alcohol may influence the development of breast and ovarian cancer.
View Article and Find Full Text PDFA Case of Malignant Transformation of an Orbital Epidermoid Cyst to Cystic Squamous Cell Carcinoma.
Ophthalmic Plast Reconstr Surg
November 2024
Article Synopsis
- Squamous cell carcinoma of the orbit is rare because there’s no squamous epithelium present, and it usually originates from skin lesions, like epidermoid cysts.
- The case study discusses a 63-year-old woman who experienced double vision and forehead pain due to an orbital lesion that was initially thought to be a ruptured epidermoid cyst.
- After surgery, she had a recurrence of symptoms, and further examination revealed that the cyst had transformed into cystic squamous cell carcinoma, highlighting the potential for malignant change in epidermoid cysts.
Genetic features of alcohol dependence have been extensively investigated in recent years. A large body of studies has underlined the important role of genetic variants not only in metabolic pathways but also in the neurobiology of alcohol dependence, mediated by the neuronal circuits regulating reward and craving. Serotonin transporter (5-HTT), encoded by the SLC6A4 gene (Solute carrier family 6-neurotransmitter transporter-member 4), is targeted by antidepressant drugs such as selective serotonin reuptake inhibitors (SSRIs) and plays a pivotal role in serotoninergic transmission; it has been associated with psychiatric diseases and alcohol dependence.
View Article and Find Full Text PDFBackground: We assessed the long-term (24 months) efficacy and safety of monthly calcifediol (0.266 mg) in the correction and maintenance of total 25(OH)D levels in postmenopausal women with basal values <30 ng/mL.
Methods: We initially enrolled 45 consecutive patients during the period September 2019-September 2020.