Technical and biological conditions influencing the functional APC resistance test.

Poor anticoagulant response to APC is conveniently screened by a commercially available functional test (Coatest APC Resistance) allowing identification of APC-resistant patients. These patients may then be genotyped with respect to factor V, the Arg -> Gln mutation being the principle cause of APC resistance. However, determination of phenotype generally precedes that of genotype, and the need for an "abnormality threshold" prompted a study of inter-batch variations and the clinical conditions associated with an altered APC response.

[Orbitopalpebral non-Hodgkin's malignant lymphoma: report on 4 cases (author's transl)].

Non-Hodgkins lymphoid neoplasm localised in the orbitopalpebral region reported in 4 women aged 65 to 86 years. The Kiel classification is described and the difficulties of pathologic diagnosis of these lymphomas emphasized.