Publications by authors named "M J Ledson"
Article Synopsis
- The UK National Screening Committee recommended low-dose CT lung cancer screening in September 2022, following successful trials that showed a decrease in lung cancer deaths.
- While these trials demonstrate clinical effectiveness, further efforts are needed to ensure the screening can be delivered on a national level.
- A group of experts, including clinicians and scientists, met to discuss implementation priorities, and their findings aim to guide the expansion of lung cancer screening programs in the UK and serve as a reference for other countries.
Background: The NLST reported a significant 20% reduction in lung cancer mortality with three annual low-dose CT (LDCT) screens and the Dutch-Belgian NELSON trial indicates a similar reduction. We present the results of the UKLS trial.
Methods: From October 2011 to February 2013, we randomly allocated 4 055 participants to either a single invitation to screening with LDCT or to no screening (usual care).
Introduction: Low-dose CT (LDCT) screening reduces lung cancer specific mortality. Several countries, including the UK, are evaluating the clinical impact and cost-effectiveness of LDCT screening using the latest evidence. In this paper we report baseline screening performance from five UK-based lung cancer screening programmes.
View Article and Find Full Text PDFObjectives: This Liverpool Healthy Lung Programme is a response to high rates of lung cancer and respiratory diseases locally and aims to diagnose lung cancer at an earlier stage by proactive approach to those at high risk of lung cancer. The objective of this study is to evaluate the programme in terms of its likely effect on mortality from lung cancer and its delivery to deprived populations.
Methods: Persons aged 58-75 years, with a history of smoking or a diagnosis of chronic obstructive pulmonary disease (COPD) according to general practice records were invited for lung health check in a community health hub setting.