Publications by authors named "M J Latham"
Background: Global progress toward malaria elimination and eradication goals has stagnated in recent years, with many African countries reporting increases in malaria morbidity and mortality. Insecticide-treated nets and indoor residual spraying are effective, but the emergence and increased intensity of insecticide resistance and the challenge of outdoor transmission are undermining their impact. New tools are needed to get back on track towards global targets.
View Article and Find Full Text PDFCultured pluripotent stem cells are unique in being the only fully diploid immortal human cell lines. However, during continued culture, they acquire significant chromosome abnormalities. Chromosome 12 trisomy is the most common whole-chromosome abnormality found during culture of human induced pluripotent stem cells (iPSCs).
View Article and Find Full Text PDFThe RNA recognition motif (RRM) is a conserved and ubiquitous RNA-binding domain that plays essential roles in mRNA splicing, polyadenylation, transport, and stability. RRM domains exhibit remarkable diversity in binding partners, interacting with various sequences of single- and double-stranded RNA, despite their small size and compact fold. During pre-mRNA cleavage and polyadenylation, the RRM domain from CSTF2 recognizes U- or G/U-rich RNA sequences downstream from the cleavage and polyadenylation site to regulate the process.
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- Biorational larvicides are essential for managing mosquito populations and mosquito-borne diseases, but effective and safe options are scarce, leading to a push for innovative formulations using existing active ingredients.
- A comparison study between OmniPrene® G and Altosid® Pellets, both containing S-methoprene, showed that while both were effective, OmniPrene G initially outperformed Altosid Pellets at lower doses.
- Over time, Altosid Pellets began to show better efficacy, particularly at higher doses, but both products demonstrated similar mortality patterns, with the majority of mosquito deaths occurring before they could emerge.
Article Synopsis
- Gerresheimer and Midas Pharma created a new autoinjector design that uses a cartridge kept under constant pressure, and analyzed the primary packaging materials for performance over time.
- The study involved testing materials from three glass manufacturers and two rubber manufacturers, focusing on how they behave under long-term pressure regarding septum stability, piercing ability, glide and break-loose forces, and the integrity of a marketed antibody drug.
- Results showed that while the cartridge septum initially bulged, it stabilized after 14 days, and no significant issues such as septum rupture or degradation of the drug were observed, indicating the design is safe and effective even under prolonged pressure.