Publications by authors named "M J La Guardia"
Biological age, which reflects the physiological state of an individual, offers a better predictive value than chronological age for age-related diseases and mortality. Nonetheless, determining accurate functional features of biological age remains challenging due to the multifactorial nature of aging. Here, we established a unique mouse cohort comprising 1576 male and female outbred SWISS mice subjected or not to high-fat, high-sucrose diet to investigate multiorgan/system biological aging throughout adulthood.
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- - The study investigates the impacts of exposure to mixtures of organophosphate esters (OPEs) and brominated flame retardants (RBFRs) on childhood respiratory issues, particularly wheeze and hay fever, in a sample of 377 pregnant women and their infants.
- - Researchers measured the levels of OPEs and RBFRs in house dust and urine at various prenatal and postnatal stages and used advanced statistical methods to analyze the results.
- - Findings indicate that increased exposure to certain OPEs during pregnancy and infancy is linked to a higher risk of respiratory problems, suggesting that these chemical mixtures could be contributing factors to adverse respiratory outcomes in children.
Few studies have considered household interventions for reducing endocrine disrupting chemical (EDC) exposures. We conducted a secondary analysis of a randomized controlled trial, originally designed to reduce lead exposure, to evaluate if the intervention lowered EDC exposures in young children. Study participants were children from the Cincinnati, Ohio area (n = 250, HOME Study).
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- * MicroRNAs (miRNAs) play key regulatory roles in viral infections, either promoting or inhibiting these infections, while viruses may also produce their own viral miRNAs (v-miRNAs) to evade host immune responses.
- * This review focuses on the structure, genome, and replication cycle of various viruses, examining how both host miRNAs and v-miRNAs contribute to the pathogenesis of these infections and the potential for new treatment strategies.