Suitability of the OMOP Common Data Model for Mapping Datasets of Medical Research Studies Using the Example of a Multicenter Registry.

Common Data Models (CDM) are developed to solve integration problems that arise in the secondary use of health data. The OMOP CDM is such a model that is mainly used for healthcare data, so this paper examines whether it is also suitable for mapping research data. An exemplary research dataset is mapped to the model and the model is tested for suitability.

Tibial Baseplate Microstructure Governs High Cycle Fatigue Fracture In Vivo.

Previous studies report rare occurrences of tibial baseplate fractures following primary total knee arthroplasty (TKA). However, at a microstructural scale, it remains unclear how fatigue models developed in vitro apply to fractures in vivo. In this study, we asked: (1) do any clinical factors differentiate fracture patients from a broader revision sample; and (2) in vivo, how does microstructure influence fatigue crack propagation? We identified three fractured tibial baseplates from an institutional review board exempt implant retrieval program.

Wear, Material Transfer, and Electrocautery Damage Are Ubiquitous on CoCrMo Femoral Knee Retrievals.

Despite high total knee arthroplasty (TKA) survivorship after 10 years (92%-99%), a gap persists where patient satisfaction lags clinical success. Additionally, while cobalt chrome molybdenum (CoCrMo) use decreases in primary total hip arthroplasty, the alloy continues to be widely used in TKA femoral components. In vivo, CoCrMo degradation may be associated with adverse local tissue reactions (ALTR) and compared with the hip, the damage mechanisms that may release metal in the knee and the potential biological effects remain poorly understood.

Congenital Abnormalities of Kidneys and Urinary Tract: A Top--Down Review of the Embryology and Imaging Appearance.

Congenital abnormalities of the kidneys and urinary tract (CAKUT) encompass a spectrum of pathology ranging in severity from incidental findings to marked deviations of anatomic form and function. The imaging appearance of CAKUT generally reflects a deviation from normal embryologic development. Common and uncommon congenital abnormalities of the kidneys, ureters, bladder, and urethra are reviewed with an emphasis on the imaging appearance and embryologic origin so that they may be promptly identified and treated when encountered in clinical practice.

The Effects of Cognitive Remediation on Negative Symptoms in Schizophrenia-Spectrum Illness: A Meta-analytic Investigation of Efficacy.

Background And Hypothesis: The number of clinical efficacy trials of Cognitive Remediation (CR), a behavioral intervention consisting of cognitive task practice and/or strategy training to improve cognitive skills in schizophrenia, has increased substantially over the past 25 years. While recent reviews have highlighted the effects of CR on cognition and function, CR effects on negative symptoms remain understudied. Given the overlap between negative symptoms and cognition, CR effects might be expected.