Comparing strategies for the mitigation of SARS-CoV-2 airborne infection risk in tiered auditorium venues.

The COVID-19 pandemic demonstrated that reliable risk assessment of venues is still challenging and resulted in the indiscriminate closure of many venues worldwide. Therefore, this study used an experimental, numerical and analytical approach to investigate the airborne transmission risk potential of differently ventilated, sized and shaped venues. The data were used to assess the magnitude of effect of various mitigation measures and to develop recommendations.

Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders.

Objectives: This study aims to elucidate the microbial signatures associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), compared with colorectal cancer (CRC), to identify unique biomarkers and shared microbial mechanisms that could inform specific treatment protocols.

Methods: We analysed metagenomic datasets from patient cohorts with six autoimmune conditions-SLE, IBD, multiple sclerosis, myasthenia gravis, Graves' disease and ankylosing spondylitis-contrasting these with CRC metagenomes to delineate disease-specific microbial profiles. The study focused on identifying predictive biomarkers from species profiles and functional genes, integrating protein-protein interaction analyses to explore effector-like proteins and their targets in key signalling pathways.

Integrated pain care models and the importance of aligning stakeholder values.

Sustained widespread deployment of clinically and cost-effective models of integrated pain care could be bolstered by optimally aligning shared stakeholder values.

Thermodynamically Guided Improvement of Fe-Mn-Al-Ni Shape-Memory Alloys.

A microstructural informed thermodynamic model is utilized to tailor the pseudoelastic performance of a series of Fe-Mn-Al-Ni shape-memory alloys. Following this approach, the influence of the stability and the amount of the B2-ordered precipitates on the stability of the austenitic state and the pseudoelastic response is revealed. This is assessed by a combination of complementary nanoindentation measurements and incremental-strain tests under compressive loading.