The primary treatment for gliomas typically involves tumor resection followed by adjuvant radiotherapy, with increasing emphasis on chemotherapy and molecularly targeted drugs. This study aimed to review and summarize the literature on the systemic therapy of malignant gliomas. Chemotherapy may be considered in grades 2 and 3 gliomas, especially when mutations in 1p19q-codeletion are detected.
View Article and Find Full Text PDFChatGPT-4 and 600 human raters evaluated 226 public figures' personalities using the Ten-Item Personality Inventory. The correlation between ChatGPT-4 and aggregate human ratings ranged from = 0.76 to 0.
View Article and Find Full Text PDFAlthough the Boari flap technique is commonly described in the literature as a method for primarily distal and middle ureteral injuries, it can also be used for reconstructing the proximal segment of the ureter. In this case study, we present a patient who underwent gynecological surgery with subsequent damage to the proximal ureter, and who underwent ureteral reconstruction using methods such as kidney mobilization, Boari flap, and psoas hitch. The postoperative period was uncomplicated, and after a six-month follow-up, the reconstructed ureter is functioning well, and the patient is in good health.
View Article and Find Full Text PDFPurpose: Mapping or matching the items in a clinical outcome assessment (COA) to concepts that define a condition is a common method for evaluating a COA's concept coverage. The purpose of this research was to address the lack of formal guidance for conducting this task by developing a framework for best practices in COA concept mapping and applying it to a case study.
Methods: To develop the framework, we examined the literature and created a draft set of best practices which was then reviewed by experienced researchers through focus groups before being finalized.