Publications by authors named "M J Kemme"
Ventricular tachycardia (VT) is a life-threatening heart rhythm and has long posed a complex challenge in the field of cardiology. Recent developments in advanced imaging modalities have aimed to improve comprehension of underlying arrhythmic substrate for VT. To this extent, high-resolution cardiac magnetic resonance (CMR) and cardiac computed tomography (CCT) have emerged as tools for accurately visualizing and characterizing scar tissue, fibrosis, and other critical structural abnormalities within the heart, providing novel insights into VT triggers and substrate.
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- - The study aims to enhance the prediction of the need for an implantable cardiac defibrillator (ICD) post-myocardial infarction by using late gadolinium enhancement (LGE) imaging combined with advanced computational modeling.
- - Researchers analyzed 40 patients with myocardial infarction, examining the relationship between heart tissue characteristics and the subsequent need for ICD therapy, finding that certain metrics related to scar tissue complexity were highly predictive of events.
- - Results indicated a significant correlation between specific metrics (like interface size between healthy and scarred tissue, and types of induced ventricular tachycardias) and the likelihood of requiring ICD therapy, suggesting improved risk stratification for high-risk patients.
Aims: AP30663 is a novel compound under development for pharmacological conversion of atrial fibrillation by targeting the small conductance Ca activated K (K2) channel. The aim of this extension phase 1 study was to test AP30663 at higher single doses compared to the first-in-human trial.
Methods: Sixteen healthy male volunteers were randomized into 2 cohorts: 6- and 8-mg/kg intravenous single-dose administration of AP30663 vs.
Background: Stereotactic arrhythmia radioablation (STAR) is a potential new therapy for patients with refractory ventricular tachycardia (VT). The arrhythmogenic substrate (target) is synthesized from clinical and electro-anatomical information. This study was designed to evaluate the baseline interobserver variability in target delineation for STAR.
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