Publications by authors named "M J Kaminsky"
Background: At present, there is no established standard treatment for frail older patients with recurrent or metastatic head and neck squamous cell carcinoma. We aimed to compare the efficacy and safety of cetuximab to those of methotrexate (the reference regimen) in this population.
Methods: This randomised, open-label, phase 3 trial was done at 20 hospitals in France.
Article Synopsis
- The management of upper aerodigestive tract cancers is intricate, prompting the creation of a reference framework to define optimal treatment principles, led by a multidisciplinary scientific committee.
- A systematic literature review was conducted to develop evidence-based recommendations that account for various patient-specific factors and treatment quality criteria.
- The comprehensive framework aims to standardize care, enhance decision-making in consultations, and ensure equitable treatment practices, with plans for future updates to maintain relevance.
Article Synopsis
- The study aims to assess the baseline symptom burden experienced by patients with recurrent ovarian cancer and its relationship with progression-free survival and overall survival.
- Analysis involved 948 patients with either platinum-resistant or potentially platinum-sensitive recurrent ovarian cancer receiving advanced chemotherapy, revealing that a significant majority experienced mild to severe symptoms, including pain, fatigue, and anxiety.
- Results showed that higher symptom burden was linked to reduced progression-free survival and overall survival, highlighting the need for effective symptom management in clinical settings and trials.
Trauma surgeons experience compassion fatigue: A major metropolitan area survey.
J Trauma Acute Care Surg
August 2024
Introduction: Compassion fatigue (CF), the physical, emotional, and psychological impact of helping others, is composed of three domains: compassion satisfaction (CS), secondary traumatic stress (STS), and burnout (BO). Trauma surgeons (TSs) experience work-related stress resulting in high rates of CF, which can manifest as physical and psychological disorders. We hypothesized that TSs experience CF and there are potentially modifiable systemic factors to mitigate its symptoms.
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