Publications by authors named "M J Irias Escher"
Article Synopsis
- Inactivation of the A20 gene is linked to a specific form of lymphoma and is studied in patients with haploinsufficiency of A20 (HA20), revealing immune system impacts.
- In a study of 34 HA20 patients, researchers found that the loss of one A20 gene copy leads to an increase in self-reactive lymphocyte receptors, often seen in lymphomas.
- The immune changes are driven by a feedback loop involving tumor necrosis factor (TNF), A20, and NF-κB, and can potentially be reversed by anti-TNF treatment, but may still lead to lymphoma development.
Article Synopsis
- Chronic HCV infection can lead to serious immune complications like B cell dyscrasias, and while antiviral therapy has reduced liver damage, its effects on these complications are still unclear.
- Researchers sequenced B cell receptors in patients with chronic HCV and those who achieved sustained virological response (SVR) after treatment, identifying patterns in neutralizing antibodies and comparing them to lymphoma data.
- Findings indicated that specific mutations in B cell receptors associated with high neutralizing activity were also found in lymphoma cases, suggesting a connection between the immune response to HCV and the persistence of potential lymphoma-like cells even after successful treatment.
Interactional competencies in medical student admission- what makes a "good medical doctor"?
Adv Health Sci Educ Theory Pract
July 2024
Doctors' interactional competencies play a crucial role in patient satisfaction, well-being, and compliance. Accordingly, it is in medical schools' interest to select candidates with strong interactional abilities. While Multiple Mini Interviews (MMIs) provide a useful context to assess such abilities, the evaluation of candidate performance during MMIs is not always based on a solid theoretical framework.
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- * In a study of 178,640 patients, those without respiratory symptoms were generally older (median age 74) and had a lower ICU admission rate (36.7%) compared to those with symptoms (37.5%).
- * Despite a higher crude in-hospital death rate for NRS patients (41.1% vs. 32.0%), after adjusting for other factors, they had a lower overall risk of death (HR 0.88), highlighting the complexity of COVID-19 presentations and outcomes.
Article Synopsis
- Antimicrobial resistance (AMR) is a significant global health issue, particularly for gonorrhoea treatment, with ceftriaxone being the last effective option, yet resistance cases from Asia have been reported.
- A study conducted by the WHO in Cambodia analyzed 437 male patients from January 2022 to June 2023, revealing resistance rates of 15.4% for ceftriaxone and high levels for other antibiotics, including 6.2% of samples being extensively drug-resistant (XDR).
- The findings emphasize the urgent need for improved AMR surveillance, updates to treatment protocols, mandatory follow-up testing, and the development of new antibiotics to effectively combat gonorrhoea.