Publications by authors named "M J Huijbers"
Endoglycosidase CU43 removes IgG Fc glycans, inhibits IgG effector functions, and prevents pathology in multiple disease models.
View Article and Find Full Text PDFArticle Synopsis
- * The research identified 12 significant genetic markers linked to MG, with certain markers associated specifically with early-onset (under 50) and late-onset (50 and older) forms of the disease.
- * Additionally, the study highlighted the potential role of genetic factors in determining the age of disease onset and demonstrated that polygenic risk scores could help predict MG status, explaining over 4% of the variation in disease presence.
Article Synopsis
- Muscle-specific kinase (MuSK) is crucial for creating and maintaining neuromuscular synapses, and its activation can help treat diseases affecting these connections, such as congenital myasthenia (CM).
- ARGX-119 is a novel humanized monoclonal antibody designed to specifically activate MuSK, improving neuromuscular junction function without disrupting the natural ligand, neural Agrin.
- In studies, ARGX-119 successfully improved neuromuscular function in mouse models of CM, showing promise for treating related neuromuscular disorders in humans, justifying its further clinical development.
Agonist antibody to MuSK protects mice from MuSK myasthenia gravis.
Julien Oury Begona Gamallo-Lana Leah Santana Christophe Steyaert Dana L E Vergoossen Maartje G Huijbers
Proc Natl Acad Sci U S A
September 2024
Article Synopsis
- Myasthenia gravis (MG) is a severe illness that causes muscle weakness because signals from nerves to muscles don't work well.
- In some types of MG, the body's immune system mistakenly attacks important proteins that help muscles respond to signals.
- Researchers found that special antibodies from MG patients can cause muscle disease in mice, but a new type of antibody can help treat it without shutting down the whole immune system.
Background: This study aimed to identify moderators of treatment effect (i.e. depressive symptoms and well-being) of Mindfulness-Based Cognitive Therapy (MBCT) and Positive Psychology Intervention (PPI) in patients with bipolar disorder.
View Article and Find Full Text PDF