Results of a patient-level pooled analysis of three studies of trastuzumab deruxtecan in HER2-positive breast cancer with active brain metastasis.

Background: Brain metastases (BMs) are common in human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer, increasing morbidity and mortality. Systemic therapy for BMs can be effective, with the triple combination of trastuzumab, capecitabine, and tucatinib being a potential standard. More recently, intracranial activity of antibody-drug conjugates has been reported, but the size of individual studies has been small.

Adolescent Idiopathic Scoliosis: Advances in Diagnosis and Management.

Purpose Of Review: Adolescent idiopathic scoliosis (AIS) is a disabling spinal pathology, with a significant morbidity if left untreated. This review investigates the recent advances in the diagnosis and management of AIS.

Recent Findings: Low radiation techniques have become a paramount focus in the management of patient's with AIS.

The Challenges and Opportunities in Pediatric Medical Device Innovation: Monitoring Devices.

Background: Medical device innovation and development for pediatric care lags behind that of adults. With higher technical risks, challenges in accumulating data, smaller market sizes, and limited return on investment, there is less incentive for pediatric device development. Consequently, translation of medical devices specifically designed to improve pediatric care is limited.

Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2.

T cells are involved in protective immunity against numerous viral infections. Data regarding functional roles of human T cells in SARS-CoV-2 (SARS2) viral clearance in primary COVID-19 are limited. To address this knowledge gap, we assessed samples for associations between SARS2 upper respiratory tract viral RNA levels and early virus-specific adaptive immune responses for 95 unvaccinated clinical trial participants with acute primary COVID-19 aged 18-86 years old, approximately half of whom were considered at high risk for progression to severe COVID-19.

Can people with longstanding bulimia nervosa suffer from severe and enduring eating disorder? A qualitative study.

Objectives: To interview a series of individuals with bulimia nervosa of longstanding to establish their symptoms and examine the suggestion, using qualitative analysis, that the term "Severe and Enduring Bulimia Nervosa (SEED-BN)" might be appropriate and helpful.

Methods: 12 participants with Bulimia Nervosa, one male, were interviewed with the help of an interview guide. Interviews were recorded and transcribed.