Publications by authors named "M J Hilz"

Background: Secondary stroke prevention in patients with atrial fibrillation (AF) is one of the fastest growing areas in the field of cerebrovascular diseases. This Scientific statement from the World Stroke Organization Brain & Heart Task Force provides a critical analysis of the strength of current evidence this topic, highlights areas of current controversy, identifies knowledge gaps, and proposes priorities for future research.

Methods: We select topics with the highest clinical relevance and perform a systematic search to answer specific practical questions.

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  • The study evaluates the state of education and training in autonomic nervous system (ANS) disorders among European neurology residents and consultants, especially after disruptions caused by the COVID-19 pandemic.
  • The research employed a 23-item online questionnaire distributed to neurology professionals, assessing demographics, training opportunities, and preferences for learning about ANS disorders.
  • Results indicated a strong desire among 285 respondents for improved education in ANS skills, with notable differences based on gender, age, and region, highlighting the need for integrating autonomic medicine into residency curricula.
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  • The study investigates the impact of fingolimod treatment on heart rate (HR) and cardiovascular autonomic modulation in patients with relapsing-remitting multiple sclerosis (RRMS), particularly focusing on those who initially experienced prolonged HR slowing.
  • It involves monitoring 34 patients before and after fingolimod initiation, measuring various cardiovascular parameters to assess changes in autonomic function.
  • Findings indicate that while all patients experienced HR decreases after treatment, those with initial prolonged HR slowing showed persistent differences in HR and autonomic modulation six months later compared to those without this phenomenon.
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Background: Fabry disease (FD), an X-linked lysosomal storage disorder, is caused by mutations in the gene encoding α-galactosidase A, resulting in lysosomal accumulation of globotriaosylceramide and other glycosphingolipids. Early detection of FD is challenging, accounting for delayed diagnosis and treatment initiation. This study aimed to develop an algorithm using a logistic regression model to facilitate early identification of patients based on ICD-10-GM coding using a German Sickness Fund Database.

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Purpose: To understand the influence of the coronavirus disease 2019 (COVID-19) pandemic on clinical autonomic education and research in Europe.

Methods: We invited 84 European autonomic centers to complete an online survey, recorded the pre-pandemic-to-pandemic percentage of junior participants in the annual congresses of the European Federation of Autonomic Societies (EFAS) and European Academy of Neurology (EAN) and the pre-pandemic-to-pandemic number of PubMed publications on neurological disorders.

Results: Forty-six centers answered the survey (55%).

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