Publications by authors named "M J Hildebrand"
Objectives: The Ryan Program collaborates with OBGYN residency programs in the United States (U.S.) to ensure that abortion and contraception care are incorporated into resident curriculum as required.
View Article and Find Full Text PDFChronic pain is a highly debilitating condition that differs by type, prevalence, and severity between men and women. To uncover the molecular underpinnings of these differences, it is critical to analyze the transcriptomes of spinal cord pain-processing networks for both sexes. Despite several recently published single-nucleus RNA-sequencing (snRNA-seq) studies on the function and composition of the mouse spinal cord, a gene expression analysis investigating the differences between males and females has yet to be performed.
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- The COVID-19 pandemic significantly altered family dynamics and potentially influenced rates of child maltreatment, prompting a need for research on reported incidents over time.
- The study analyzed 11 articles and several grey literature reports, focusing on monthly counts of child maltreatment reports during the pandemic, comparing them to pre-pandemic data.
- Findings showed a decrease in overall reported incidents, but the changes varied by reporter type; the study emphasizes the need for more research and better responses for child protection as vulnerabilities may rise.
Article Synopsis
- The study investigates the connection between the TOGARAM gene family, specifically TOGARAM1, and spina bifida, a neural tube closure defect in embryonic development.
- Researchers found that Togaram1 is important for proper neural tube formation and identified its role in cilia function and sonic hedgehog (Shh) signaling.
- Findings from knockout mice and cell overexpression studies suggest that variations in TOGARAM1 could lead to defects that contribute to the development of spina bifida in patients.
Excitatory glutamatergic NMDA receptors (NMDARs) are key regulators of spinal pain processing, and yet the biophysical properties of NMDARs in dorsal horn nociceptive neurons remain poorly understood. Despite the clinical implications, it is unknown whether the molecular and functional properties of synaptic NMDAR responses are conserved between males and females or translate from rodents to humans. To address these translational gaps, we systematically compared individual and averaged excitatory synaptic responses from lamina I pain-processing neurons of adult Sprague-Dawley rats and human organ donors, including both sexes.
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