Publications by authors named "M J Hickson"
Objectives: To determine whether daily provision of a high protein, high energy meal for 12-weeks to under-nourished older adults living independently in the community can improve physical, physiological, and psychological outcomes.
Design: A randomised crossover trial.
Setting: Participant homes within a 15-mile radius to meal supplier; Dartmoor Community Kitchen Hub.
Article Synopsis
- In a study on children with Phenylketonuria (PKU), casein glycomacropeptide (GMP) was compared to phenylalanine-free amino acids (AA) as a protein substitute, focusing on digestion and overall health effects.
- Results showed that GMP significantly improved gastrointestinal symptoms like stomach pain and bloating, although it did not have a major impact on other health markers like renal function or oxidative stress.
- However, GMP's higher phenylalanine content poses challenges for use as a sole protein source in PKU kids due to their low tolerance for phenylalanine.
Article Synopsis
- In a study on phenylketonuria (PKU), data from 1323 patients across nine European and Turkish centers revealed that natural protein intake rises with age, especially during childhood and adolescence, while lifelong phenylalanine tolerance remains unclear.
- The research collected dietary intake information from 2012 to 2018, showing varying tolerances among different PKU classifications, with patients having mild PKU tolerating about 50% more phenylalanine than those with classical PKU.
- Additionally, the study highlighted that natural protein intake significantly increased for patients using sapropterin, with notable geographical differences in protein tolerance observed between Southern and Northern Europe.
Background: Four out of five people living with osteoarthritis (OA) also suffer with at least one other long-term health condition. The complex interaction between OA and multiple long-term conditions (MLTCs) can result in difficulties with self-care, restricted mobility, pain, anxiety, depression and reduced quality of life. The aim of the MulTI-domain Self-management in Older People wiTh OstEoarthritis and Multi-Morbidities (TIPTOE) trial is to evaluate the clinical and cost-effectiveness of the Living Well self-management support intervention, co-designed with people living with OA, integrated into usual care, in comparison to usual care alone.
View Article and Find Full Text PDFBackground: Green leafy vegetables (GLV) contain inorganic nitrate, an anion with potential prebiotic effects on the oral microbiome. However, it remains unclear whether GLV and pharmacological supplementation [potassium nitrate (PN)] with a nitrate salt induce similar effects on the oral microbiome.
Objectives: This study aimed to compare the effect of GLV with PN supplementation on the oral microbiome composition and salivary biomarkers in individuals with high blood pressure.