Publications by authors named "M J Hardman"
Article Synopsis
- A 57-year-old man experienced significant weight loss and health complications five weeks after surgery for a Type A aortic dissection.
- The surgery involved a hemiarch repair and bypass due to ischemia in his right leg.
- His post-operative issues were linked to a dissection flap affecting blood flow to the superior mesenteric artery, illustrating the potential difficulties that can arise after such urgent repairs.
Unlabelled: Chronic lung infections are the primary cause of morbidity and early mortality in cystic fibrosis (CF) and, as such, have been the subject of a great deal of research. Subsequently, they have become one of the key paradigms for polymicrobial infections. The literature, however, has traditionally focused on the presence of pathogens in isolation or univariate measures like number of species to predict decline of lung function and ignores large swathes of data.
View Article and Find Full Text PDFBackground: Intraventricular hemorrhage is a calamitous type of stroke where bleeding into the ventricular system can be defined as: primary, if confined within the ventricles; or secondary, due to intracerebral hemorrhage extending from adjacent parenchyma. Intraventricular blood clot can lead to secondary insult and inflammatory responses that culminates in hydrocephalus as the most common cause of death.
Purpose: THerein, we report a patient with a high modified Graeb scale and low Glasgow coma scale.
Article Synopsis
- - This study explores how low concentrations of fluoxetine (Prozac), found in polluted water, affect wound healing, highlighting a gap in understanding its impact on humans.
- - The research demonstrated that exposure to fluoxetine accelerated wound closure in human skin cells, showing dose-dependent effects starting from a concentration of 125 ng/l.
- - Mechanistically, fluoxetine enhances wound healing by increasing cell proliferation and altering serotonin signaling, which involves significant changes in gene expression and protein activity linked to cell growth and metabolism.
Biomaterials capable of promoting wound healing and preventing infections remain in great demand to address the global unmet need for the treatment of chronic wounds. Phosphate-based glasses (PG) have shown potential as bioresorbable materials capable of inducing tissue regeneration, while being replaced by regenerated tissue and releasing therapeutic species. In this work, phosphate-glass-based fibers (PGF) in the system PO-CaO-NaO added with 1, 2, 4, 6, and 10 mol % of the therapeutic metallic ions (TMI) Ag, Zn, and Fe were manufactured via electrospinning of coacervate gels.
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