Publications by authors named "M J Guerquin"
The generation of oocytes from induced pluripotent stem cells (iPSCs) was proven efficient with mouse cells. However, no human iPSCs have yet been reported to generate cells able to complete oogenesis. Additionally, efficient sorting of human Primordial Germ Cell- Cells (hPGC-LCs) without genomic integration of fluorescent reporter for their downstream manipulation is still lacking.
View Article and Find Full Text PDFArticle Synopsis
- Many endocrine disruptors, like Bisphenol A (BPA), negatively affect meiosis, a process crucial for healthy gamete production, leading to conditions like oocyte aneuploidy.
- Research on BPA alternatives, such as BADGE and BPAF, reveals they also delay meiosis, increase specific foci in cells, and cause defects in gene expression and DNA integrity during oogenesis in mice.
- The study suggests that oxidative DNA damage may be a common harmful mechanism in female meiosis caused by various environmental pollutants, highlighting the need to reevaluate the risks of mixtures of bisphenols found in our surroundings.
For decades, numerous chemical pollutants have been described to interfere with endogenous hormone metabolism/signaling altering reproductive functions. Among these endocrine disrupting substances, Bisphenol A (BPA), a widely used compound, is known to negatively impact germ and somatic cells in the testis. Physical agents, such as ionizing radiation, were also described to perturb spermatogenesis.
View Article and Find Full Text PDFExposure to Metformin Reduces the Fertility of Male Offspring in Adulthood.
Front Endocrinol (Lausanne)
February 2022
Metformin is a drug used for the treatment of type 2 diabetes and disorders associated with insulin resistance. Metformin is also used in the treatment of pregnancy disorders such as gestational diabetes. However, the consequences of foetal exposure to metformin on the fertility of exposed offspring remain poorly documented.
View Article and Find Full Text PDFResearch Question: What is the impact of radiation exposure on oocyte quality and female fertility?
Design: Prepubertal mice underwent whole-body irradiation with a single dose (0.02, 0.1, 0.